Amylyx Pharmaceuticals, Inc. (AMLX) Institutional Ownership
As of the Mar 31, 2026 13F filing cycle, 144 institutions reported holding Amylyx Pharmaceuticals, Inc. (AMLX), together worth $1.47B. Compared to Dec 31, 2025: 65 increased their position, 0 opened a new one, 52 trimmed, and 0 fully exited, a net addition of 2.43M shares. The 10 largest institutional holders control +63% of all institutionally-held shares. Notable names on the list include TWO SIGMA INVESTMENTS, LP, CITADEL ADVISORS LLC, Point72 Asset Management, L.P..
As of the Mar 31, 2026 13F filing cycle, compared to Dec 31, 2025. Institutions have up to 45 days after quarter-end to file, so this can lag real-time positioning.
The largest position increases, new positions, decreases, and confirmed exits this cycle. Percent-change lists below require at least a $1M prior-quarter position, so a fund going from a handful of shares to a few thousand does not crowd out real, sized moves.
A small, non-exhaustive list of well-known funds and passive index giants we checked for by name, not a comprehensive classification of every institution on record.
These alone represent about +13% of total institutional value on record, a rough floor for index-driven (not conviction-driven) ownership.
"Since prior quarter" return uses each holder's prior-quarter value divided by prior-quarter shares as a rough implied entry price, not their real cost basis, which is not disclosed in 13F filings.
| Institution | Status | Shares | Value | Change | Since Prior Qtr |
|---|---|---|---|---|---|
| FMR LLC | Increased | 16.63M | $231.16M | +0.68% | +187.6% |
| BlackRock, Inc. | Decreased | 8.83M | $122.72M | -2.49% | +187.6% |
| PERCEPTIVE ADVISORS LLC | Unchanged | 8.28M | $115.16M | 0.00% | +187.6% |
| TCG Crossover Management, LLC | Unchanged | 6.24M | $86.79M | 0.00% | +187.6% |
| Commodore Capital LP | Unchanged | 5.65M | $78.53M | 0.00% | +187.6% |
| VANGUARD GROUP INC | Unclear (Last Known) | 5.80M | $70.12M | — | +187.6% |
| JANUS HENDERSON GROUP PLC | Increased | 4.99M | $69.26M | +11.65% | +187.3% |
| Saturn V Capital Management LP | Decreased | 4.35M | $60.46M | -3.26% | +187.6% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Increased | 3.56M | $49.49M | +28.22% | +187.6% |
| First Light Asset Management, LLC | Decreased | 3.19M | $44.35M | -4.91% | +187.6% |
| Driehaus Capital Management LLC | Decreased | 2.99M | $41.52M | -3.93% | +187.6% |
| GOLDMAN SACHS GROUP INC | Increased | 2.63M | $36.50M | +0.49% | +187.6% |
| STATE STREET CORP | Increased | 2.36M | $32.85M | +14.17% | +187.6% |
| FRANKLIN RESOURCES INC | Increased | 2.26M | $31.44M | +88.45% | +187.6% |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 2.21M | $30.74M | +2.10% | +187.5% |
| MORGAN STANLEY | Decreased | 2.18M | $30.24M | -7.81% | +187.6% |
| Almitas Capital LLC | Unchanged | 2.12M | $29.50M | 0.00% | +187.6% |
| GREAT POINT PARTNERS LLC | Unchanged | 1.75M | $24.32M | 0.00% | +187.6% |
| 683 Capital Management, LLC | Decreased | 1.63M | $22.61M | -1.42% | +187.6% |
| EVENTIDE ASSET MANAGEMENT, LLC | Increased | 1.51M | $21.04M | +0.05% | +187.6% |
How many institutions hold AMLX stock?
144 institutions reported a position in Amylyx Pharmaceuticals, Inc. as of the Mar 31, 2026 13F filing cycle, worth a combined $1.47B.
Are institutions buying or selling AMLX?
Comparing Mar 31, 2026 to Dec 31, 2025: 65 institutions increased their position and 0 opened new ones, while 52 decreased and 0 fully exited. Net share change: 2.43M.
How concentrated is institutional ownership of AMLX?
The top 10 institutional holders control +63% of all shares held by institutions on record, a fairly concentrated group of holders.
How current is this institutional ownership data?
This reflects the Mar 31, 2026 13F filing cycle. Institutional investors have up to 45 days after quarter-end to file, so this data can lag real-time positioning by 1-3 months, and only U.S.-registered institutional managers above the SEC's reporting threshold are required to file at all.