Amylyx Pharmaceuticals, Inc. (AMLX)

Caution
Caution: carries more cash than debt
$34.74
Last close
+268.8%
1-year return
AMLX Bull Case vs. Bear Case

A data-driven read of AMLX's strengths and risk factors, built from its financials, earnings history, analyst activity, and insider trading, not opinion or speculation.

Strengths
Holds more cash & investments than debt (net cash position).
Analyst coverage has grown 200% over the history on record.
Analyst consensus is Strong Buy across 9 analysts.
Watch Items
Revenue declined 100.0% year over year.
Free cash flow was negative in the most recent year.
Share count grew 60.1% year over year, meaningful dilution.
Accounts receivable grew -80.3%, notably faster than revenue's -100.0%.
On a 3-quarter EPS miss streak.
Beats EPS estimates only 22% of the time.
Who's Bullish on AMLX, and Who Isn't

Five independent market signals, analysts, institutions, insiders, short sellers, and price trend, each scored from real, current data. See exactly where the smart money agrees, and where it's split.

Signals are mixed: 3 of 5 available lean bullish, 2 lean bearish.

Institutions
2.43M shares net this 13F cycle
Insiders
Net selling
Analysts
Strong Buy consensus, 9 analysts
Short Sellers
Short interest rising, 1 straight reports
Price Trend
Uptrend, price above a rising 50-day average
Valuation check: Analyst price targets have been rising even as revenue growth has been slowing, worth a closer look at what's driving the optimism.
AMLX's Biggest Trading Days

Every trading day in the last 2 years where AMLX moved 4% or more in a single session, most recent first, a quick read on how volatile this stock has really been. See full daily price history →

DateMoveClose
Aug 28, 2026-6.56%$34.74
Aug 19, 2026+80.12%$38.60
Aug 11, 2026+4.23%$23.63
Aug 7, 2026-5.66%$22.82
Aug 6, 2026+10.71%$24.19
Aug 4, 2026+8.43%$21.87
Jul 30, 2026+5.17%$20.75
Jul 27, 2026+5.87%$19.49
Jul 24, 2026+4.66%$18.41
Jul 22, 2026-4.32%$17.70
Jul 21, 2026+6.02%$18.50
Jul 17, 2026+4.29%$17.75
Jul 16, 2026-4.27%$17.02
Jul 14, 2026+4.54%$18.20
Jun 29, 2026+5.12%$18.70
Jun 15, 2026+4.11%$15.19
Jun 12, 2026+4.89%$14.59
Jun 9, 2026+4.15%$13.55
Jun 5, 2026-6.92%$13.32
Jun 4, 2026+8.41%$14.31
Jun 2, 2026-5.54%$13.29
May 20, 2026+6.83%$13.61
May 15, 2026-4.32%$13.28
May 14, 2026-4.80%$13.88
May 7, 2026-5.35%$15.20

Showing the 25 most recent of 160 on record. Full history is on the Price Insights page.

The AMLX Timeline: Earnings, Insider Trades & Analyst Calls

Every major event from the past 12 months, earnings reports, insider transactions, and analyst upgrades or downgrades, merged into a single chronological feed so you can see what clustered together.

EAug 6, 2026Q2 '26 earnings: missed EPS-11.4% surprise
IJul 10, 2026Mazzariello Gina: Sale$264K
IJul 9, 2026Mazzariello Gina: Sale$275K
IMay 21, 2026Firestone Karen: Purchase$51K
EMay 7, 2026Q1 '26 earnings: missed EPS-7.4% surprise
EMar 3, 2026Q4 '25 earnings: missed EPS-1.8% surprise
IMar 2, 2026Mazzariello Gina: Sale$99K
IMar 2, 2026FRATES JAMES M: Sale$115K
IMar 2, 2026Bedrosian Camille L: Sale$94K
IMar 2, 2026Cohen Joshua B: Sale$424K
IMar 2, 2026Klee Justin B.: Sale$424K
IFeb 23, 2026Mazzariello Gina: Sale$48K
IFeb 2, 2026Klee Justin B.: Sale$228K
IFeb 2, 2026Mazzariello Gina: Sale$51K
IFeb 2, 2026Cohen Joshua B: Sale$228K
IFeb 2, 2026FRATES JAMES M: Sale$52K
IJan 16, 2026Klee Justin B.: Sale$28K
IJan 16, 2026Cohen Joshua B: Sale$27K
IJan 15, 2026Klee Justin B.: Sale$1,850K
IJan 15, 2026Cohen Joshua B: Sale$1,851K
IJan 6, 2026Klee Justin B.: Sale$86K
IJan 6, 2026Cohen Joshua B: Sale$86K
IJan 6, 2026FRATES JAMES M: Sale$37K
IDec 23, 2025Firestone Karen: Purchase$101K
IDec 1, 2025Bedrosian Camille L: Sale$94K
Sector
Healthcare
Industry
Drug Manufacturers - Specialty & Generic
Exchange
NASDAQ
Website

Amylyx Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, engages in the discovery and development of treatment options for neurodegenerative diseases and endocrine conditions in the United States. It provides Avexitide, an investigational, first-in-class glucagon-like peptide-1, or GLP-1 receptor antagonist, which is in phase 3 clinical trial to treat post-bariatric hypoglycemia and congenital hyperinsulinism. The company also develops AMX0035, an oral, fixed-dose combination of sodium phenylbutyrate and taurursodiol which is phase 2 clinical trial for the treatment of wolfram syndrome, as well as in phase 2b/3 clinical trial to treat progressive supranuclear palsy; AMX0114, which is in phase 1 clinical trial for the treatment of amyotrophic lateral sclerosis; and long-acting GLP-1 receptor antagonist to treat post-bariatric hypoglycemia and other rare diseases. Further, it develops AMX0318, a GLP-1 receptor antagonist for the treatment of post-bariatric hypoglycemia and other rare diseaees. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.

55 Cambridge Parkway, Cambridge, MA, 02142, United States, 617 682 0917

AMLX By the Numbers

A complete statistical profile built from AMLX's full price, financial, and ownership history, not an isolated snapshot. Explore any category in depth below.

Price & Momentum
Full price insights →
Volatility regime
Unusually wild
52-week range position
84%
Trend
Uptrend, price above a rising 50-day average
Current streak
1d down
View full historical prices →
Financial Health
Full financial statements →
Revenue growth
Contracting
FCF conversion
85%
Net cash
$316.98M
Share count, 1yr
+60.1%
Earnings
Full earnings history →
EPS beat rate
+22%
Current streak
3q miss
Analyst Coverage
Full analyst ratings →
Consensus
Strong Buy
Avg target upside
-36.0%
Target agreement
Wide disagreement
Insider Activity
Full insider transactions →
Net flow
-$7.77M
Transactions on record
29
Short Interest
Full short interest →
Shares short
13.4M
Days-to-cover percentile
73th
Days to cover
6.8
Institutional Ownership
Full institutional holders →
Total holders
144
Net flow this cycle
$220.66M
Top 10 concentration
+63%
This overview draws together AMLX's price action, fundamentals, and market activity into one view, click through any section above for the full underlying analysis. The bull/bear breakdown and agreement matrix combine independently-sourced signals and are not a recommendation; any single signal can be wrong, and agreement between them is not a guarantee of future performance. This is historical data, not investment advice. Read disclaimer →